Transmembrane Emp24 Domain-Containing Protein 2 (TMED2) Antibody (HRP)

Product specifications

Primary Antibodies

Transmembrane Emp24 Domain-Containing Protein 2 (TMED2)

Rabbit

Human

Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

HRP

IgG

> 95%

Purified by Protein G.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.

No

Q15363

10959

TMED2, RNP24,p24 family protein beta-1,p24beta1

Antibody anti-TMED2

RUO

Descripción

TMED2, a member of the p24 family, functions as a cargo receptor and vesicle trafficking regulator in the early secretory pathway, mediating protein transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It is a key component of the COPII vesicle coat complex, where it assists in the selective packaging and transport of secretory and membrane proteins. TMED2 also regulates the recycling of vesicles back to the ER through interactions with the COPI coat complex, ensuring efficient cargo flow and ER-Golgi communication. It is highly expressed in tissues with active protein secretion and participates in processes such as receptor trafficking, organelle integrity, and cellular homeostasis. Dysregulation of TMED2 has been implicated in developmental defects, metabolic diseases, and cancers, where altered protein sorting disrupts cellular signaling and growth. Knockdown studies show impaired vesicle transport, disrupted Golgi architecture, and ER stress, highlighting its critical role in maintaining vesicular trafficking, protein quality control, and cellular function.

Related Products

TMED2 antibody

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors(GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

Ver Producto

Transmembrane Emp24 Domain-Containing Protein 2 (TMED2) Antibody

TMED2 Antibody is a Rabbit Polyclonal against TMED2.

Ver Producto

Transmembrane Emp24 Domain-Containing Protein 2 (TMED2) Antibody

TMED2 Antibody is a Rabbit Polyclonal against TMED2.

Ver Producto