Transmembrane emp24 domain-containing protein 2 (TMED2) Antibody
260€ (50 µl)
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Name
Transmembrane emp24 domain-containing protein 2 (TMED2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241317
Tested Applications
ELISA, IHC
Description
TMED2 Antibody is a Rabbit Polyclonal against TMED2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Transmembrane emp24 domain-containing protein 2 (TMED2) Immunogen: Fusion protein of human TMED2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15363 |
| Gene ID | 10959 |
| Alias | TMED2, RNP24,p24 family protein beta-1,p24beta1 |
| Background | Antibody anti-TMED2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TMED2, a member of the p24 family, functions as a cargo receptor and vesicle trafficking regulator in the early secretory pathway, mediating protein transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It is a key component of the COPII vesicle coat complex, where it assists in the selective packaging and transport of secretory and membrane proteins. TMED2 also regulates the recycling of vesicles back to the ER through interactions with the COPI coat complex, ensuring efficient cargo flow and ER-Golgi communication. It is highly expressed in tissues with active protein secretion and participates in processes such as receptor trafficking, organelle integrity, and cellular homeostasis. Dysregulation of TMED2 has been implicated in developmental defects, metabolic diseases, and cancers, where altered protein sorting disrupts cellular signaling and growth. Knockdown studies show impaired vesicle transport, disrupted Golgi architecture, and ER stress, highlighting its critical role in maintaining vesicular trafficking, protein quality control, and cellular function.
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