Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) Antibody
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Description
TRPM8 Antibody is a Rabbit Polyclonal Antibody against TRPM8.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z2W7 |
| Gene ID | 79054 |
| NCBI Accession | NP_076985.4 |
| Background | Antibody anti-TRPM8 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration(PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol-and cold-induced channel activity by stabilizing the closed state of the channel.
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Transient Receptor Potential Cation Channel Subfamily M Member 8 (TRPM8) Antibody
TRPM8 Antibody is a Rabbit Polyclonal Antibody against TRPM8.
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