Transcription Factor Ap-2-Alpha (TFAP2A) DNA-Binding ELISA Kit
559€ (96 tests)
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935106861
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name
Transcription Factor Ap-2-Alpha (TFAP2A) DNA-Binding ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx596462
tested applications
ELISA
Description
AP-2 DNA-Binding ELISA Kit is an ELISA Kit against AP-2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transcription Factor Ap-2-Alpha (TFAP2A) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P05549 |
| Gene ID | 7020 |
| OMIM | 107580 |
| Alias | AP-2,BOFS,AP2TF,TFAP2,AP-2alpha,Activating enhancer-binding protein 2-alpha,Activator protein 2 |
| Background | Elisa Kits for: TFAP2A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TFAP2A is a transcription factor belonging to the AP-2 family, which regulates gene expression during embryonic development, cell differentiation, and proliferation. TFAP2A binds to GC-rich promoter sequences and modulates the transcription of target genes involved in neural crest formation, craniofacial development, and epidermal differentiation. It plays a critical role in organogenesis, particularly in the development of the face, limbs, and neural tube, by controlling cell fate specification and survival. TFAP2A is also involved in tumor suppression and oncogenesis, where it regulates genes associated with apoptosis, cell cycle progression, and epithelial-mesenchymal transition (EMT). Dysregulation of TFAP2A is linked to developmental disorders such as branchio-oculo-facial syndrome (BOFS) and cancers, including breast, melanoma, and ovarian cancer, where its altered expression drives abnormal cell growth and metastasis. Knockout studies demonstrate severe developmental defects, including craniofacial abnormalities and disrupted neural crest cell differentiation, highlighting TFAP2A's essential role in embryogenesis, tissue development, and gene regulation.
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