Transcription Factor Ap-2-Alpha (TFAP2A) Antibody

Este producto es parte de TFAP2 - Transcription factor AP-2 alpha
Product Graph
364€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Transcription Factor Ap-2-Alpha (TFAP2A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx239954
tested applications
ELISA, WB

Description

Transcription Factor Ap-2-Alpha (TFAP2A) Antibody is a Mouse Monoclonal antibody for the detection of TFAP2A.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Transcription Factor Ap-2-Alpha (TFAP2A)
Host
Mouse
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/2000 - 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P05549
Gene ID
7020
OMIM
107580
Alias
AP-2,BOFS,AP2TF,TFAP2,AP-2alpha,Activating enhancer-binding protein 2-alpha,Activator protein 2
Background
Antibody anti-TFAP2A
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

TFAP2A is a transcription factor belonging to the AP-2 family, which regulates gene expression during embryonic development, cell differentiation, and proliferation. TFAP2A binds to GC-rich promoter sequences and modulates the transcription of target genes involved in neural crest formation, craniofacial development, and epidermal differentiation. It plays a critical role in organogenesis, particularly in the development of the face, limbs, and neural tube, by controlling cell fate specification and survival. TFAP2A is also involved in tumor suppression and oncogenesis, where it regulates genes associated with apoptosis, cell cycle progression, and epithelial-mesenchymal transition (EMT). Dysregulation of TFAP2A is linked to developmental disorders such as branchio-oculo-facial syndrome (BOFS) and cancers, including breast, melanoma, and ovarian cancer, where its altered expression drives abnormal cell growth and metastasis. Knockout studies demonstrate severe developmental defects, including craniofacial abnormalities and disrupted neural crest cell differentiation, highlighting TFAP2A's essential role in embryogenesis, tissue development, and gene regulation.

Related Products

EH12913

Human TFAP2A/AP-2 (Transcription factor AP-2-alpha) ELISA Kit

Ver Producto
FNab08617

TFAP2A antibody

Ver Producto
FNab09980

TFAP2A antibody

Ver Producto