Transcription Factor AP-2 Alpha (Tfap2a) Antibody

Este producto es parte de TFAP2 - Transcription factor AP-2 alpha
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273€ (200 µl)

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935106861
info@markelab.com
name
Transcription Factor AP-2 Alpha (Tfap2a) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433355
tested applications
P-ELISA

Description

Tfap2a Antibody is a Goat Polyclonal antibody against Tfap2a.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Transcription Factor AP-2 Alpha (Tfap2a)
Host
Goat
Reactivity
Zebrafish
Recommended Dilution
P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_789829.1
Alias
AP-2,BOFS,AP2TF,TFAP2,AP-2alpha,Activating enhancer-binding protein 2-alpha,Activator protein 2
Background
Antibody anti-TFAP2A
Status
RUO
Note
Concentration: 0.5 mg/ml -

Descripción

TFAP2A is a transcription factor belonging to the AP-2 family, which regulates gene expression during embryonic development, cell differentiation, and proliferation. TFAP2A binds to GC-rich promoter sequences and modulates the transcription of target genes involved in neural crest formation, craniofacial development, and epidermal differentiation. It plays a critical role in organogenesis, particularly in the development of the face, limbs, and neural tube, by controlling cell fate specification and survival. TFAP2A is also involved in tumor suppression and oncogenesis, where it regulates genes associated with apoptosis, cell cycle progression, and epithelial-mesenchymal transition (EMT). Dysregulation of TFAP2A is linked to developmental disorders such as branchio-oculo-facial syndrome (BOFS) and cancers, including breast, melanoma, and ovarian cancer, where its altered expression drives abnormal cell growth and metastasis. Knockout studies demonstrate severe developmental defects, including craniofacial abnormalities and disrupted neural crest cell differentiation, highlighting TFAP2A's essential role in embryogenesis, tissue development, and gene regulation.

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