TRAF3 Interacting Protein 2 (TRAF3IP2) Antibody

Background

RAF3-interacting protein 2 (TRAF3IP2), also known as Act1, is an adaptor protein that plays a key role in the regulation of inflammatory and immune responses by linking receptors such as IL-17 and CD40 to downstream signaling pathways. It interacts with TRAF family proteins to activate NF-kappa-B, MAPKs, and other transcriptional regulators critical for cytokine production and immune cell activation. TRAF3IP2 is essential for IL-17-mediated signaling, contributing to pro-inflammatory responses in autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. It also regulates B-cell survival and antibody production through interactions with CD40 and BAFF receptor pathways. Dysregulation or mutations in TRAF3IP2 are associated with increased inflammation, immune dysregulation, and susceptibility to certain cancers.