TNF Receptor Superfamily Member 5 / TNFRSF5 Phospho-Thr254 (CD40 pT254) Antibody
429€ (100 µl)
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Name
TNF Receptor Superfamily Member 5 / TNFRSF5 Phospho-Thr254 (CD40 pT254) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx333073
Tested Applications
ELISA, WB
Description
CD40 (pT254) Antibody is a Rabbit Polyclonal against CD40 (pT254).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Superfamily Member 5 / TNFRSF5 Phospho-Thr254 (CD40 pT254) Immunogen: Peptide sequence around phosphorylation site of threonine 254 (Q-E-T (p)-L-H) derived from Human TNFRSF5. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25942 |
| Gene ID | 958 |
| Alias | p50,Bp50,CDW40,TNFRSF5,Tumor necrosis factor receptor superfamily member 5,B-cell surface antigen CD40,CD40L receptor,CDw40,CD40 |
| Background | Antibody anti-CD40 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD40 is a co-stimulatory protein primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells (DCs), macrophages, and certain types of endothelial cells. This molecule plays a critical role in both innate and adaptive immune responses. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, specifically classified as TNFRSF5. CD40 is essential for initiating and sustaining immune responses, particularly by interacting with its ligand, CD40L (CD154), which is predominantly expressed on activated T cells. The CD40-CD40L interaction is a central element in immune regulation, providing necessary signals for B cell activation, differentiation, and class switching during antibody responses. Furthermore, CD40 signaling influences macrophage activation, dendritic cell maturation, and cytokine production, all of which are crucial for orchestrating immune responses.
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