TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody
52€ (10 µg)
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Name
TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx013215
Tested Applications
ELISA, WB, IHC
Description
Rabbit polyclonal antibody against CD40 protein. Immunogen region is C-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human CD40. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25942 |
| Alias | p50,Bp50,CDW40,TNFRSF5,Tumor necrosis factor receptor superfamily member 5,B-cell surface antigen CD40,CD40L receptor,CDw40,CD40 |
| Background | Antibody anti-CD40 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD40 is a co-stimulatory protein primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells (DCs), macrophages, and certain types of endothelial cells. This molecule plays a critical role in both innate and adaptive immune responses. It is a member of the tumor necrosis factor receptor (TNFR) superfamily, specifically classified as TNFRSF5. CD40 is essential for initiating and sustaining immune responses, particularly by interacting with its ligand, CD40L (CD154), which is predominantly expressed on activated T cells. The CD40-CD40L interaction is a central element in immune regulation, providing necessary signals for B cell activation, differentiation, and class switching during antibody responses. Furthermore, CD40 signaling influences macrophage activation, dendritic cell maturation, and cytokine production, all of which are crucial for orchestrating immune responses.
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