Thromboxane A2 Receptor (TBXA2R) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Thromboxane A2 Receptor (TBXA2R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005931
tested applications
WB
Description
TBXA2R Antibody is a Rabbit Polyclonal Antibody against TBXA2R.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Thromboxane A2 Receptor (TBXA2R) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21731 |
| Gene ID | 6915 |
| NCBI Accession | NP_001051.1 |
| Alias | TBXA2R,prostanoid TP receptor,TXA2-R,BDPLT13 |
| Background | Antibody anti-TBXA2R |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The thromboxane A2 receptor (TBXA2R), also known as TP, is a G protein-coupled receptor activated by thromboxane A2 (TXA2), a lipid mediator that promotes vasoconstriction, platelet aggregation, and inflammation. TBXA2R primarily couples to Gq and G12/13 proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and triggering Rho-mediated pathways that regulate smooth muscle contraction and platelet activation. TBXA2R is highly expressed in platelets, vascular smooth muscle cells, and immune cells, where it plays a pivotal role in hemostasis, thrombosis, and vascular tone. Dysregulation of TBXA2R signaling contributes to thrombotic disorders, hypertension, and atherosclerosis. TBXA2R antagonists, such as terutroban, are being developed as antithrombotic agents to reduce platelet aggregation and treat cardiovascular diseases. Targeting TBXA2R provides therapeutic potential for managing thrombosis, pulmonary hypertension, and inflammatory vascular diseases by modulating TXA2-mediated effects.
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