Thrombopoietin Receptor / CD110 (MPL) Antibody
273€ (100 µl)
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935106861
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name
Thrombopoietin Receptor / CD110 (MPL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104171
tested applications
WB
Description
Polyclonal Antibody to Myeloproliferative Leukemia Virus Oncogene (MPL).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Thrombopoietin Receptor / CD110 (MPL) Immunogen: abx068134 - Recombinant MPL (Ser311-Gln460) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.39 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P40238 |
| Gene ID | 4352 |
| OMIM | 159530 |
| Alias | MPL proto-oncogene, MPLV,TPOR,C-MPL,CD110,THPOR,THCYT2,PO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl |
| Background | Antibody anti-MPL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
MPL, also known as the thrombopoietin receptor, is a critical component in hematopoiesis, particularly for the regulation and production of platelets. It is the cellular receptor for thrombopoietin (TPO), a hormone produced primarily by the liver that promotes the proliferation and maturation of megakaryocytes, the precursors to platelets. MPL is a member of the type I cytokine receptor family and is essential for maintaining platelet counts within physiological ranges. Its activity regulates not only the production of platelets but also has implications in stem cell maintenance and self-renewal within the hematopoietic system. MPL is encoded by the MPL gene located on chromosome 1 (1p34) in humans. Mutations in this gene are associated with various myeloproliferative disorders and hematological diseases, including essential thrombocythemia, primary myelofibrosis, and certain leukemias. Due to its central role in platelet production and stem cell maintenance, MPL is a significant focus of research for understanding hematopoietic disorders and developing targeted therapies.
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Human Thrombopoietin Receptor / CD110 (MPL) Protein
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