Tetraspanin 7 (TSPAN7) Antibody
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Description
Tetraspanin 7 (TSPAN7) Antibody is a Rabbit Polyclonal antibody against Tetraspanin 7 (TSPAN7).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tetraspanin 7 (TSPAN7) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41732 |
| Gene ID | 7102 |
| Alias | Membrane component chromosome X surface marker 1,A15,MXS1,CD231, MRX58,CCG-B7,TM4SF2,XLID58,T-cell acute lymphoblastic leukemia-associated antigen 1,TALLA-1 |
| Background | Antibody anti-TSPAN7 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Tetraspanin 7 (TSPAN7) is a member of the tetraspanin superfamily, a group of membrane proteins involved in various cellular functions such as signaling, adhesion, and intracellular trafficking. Tetraspanins are characterized by their distinctive structure, containing four transmembrane domains. TSPAN7 is primarily expressed in the central nervous system, particularly in neurons, and is also found in certain immune cells. TSPAN7 is of interest due to its involvement in neurological processes and its role in neurodevelopmental disorders, most notably X-linked intellectual disability (XLID). Mutations or dysregulation of TSPAN7 have been implicated in cognitive deficits, autism spectrum disorders, and other neurological conditions, highlighting its importance in normal brain function. The primary role of TSPAN7 appears to be in facilitating cell-cell interactions and maintaining synaptic function. Through its association with other proteins in the tetraspanin web—an organized network of tetraspanins and their partner proteins—TSPAN7 modulates cellular signaling pathways crucial for neuronal growth, differentiation, and communication. These functions make TSPAN7 essential for neural development and synaptic plasticity, processes that underlie learning and memory.
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Tetraspanin-7 (TSPAN7) Antibody
TSPAN7 Antibody is a Rabbit Polyclonal antibody against TSPAN7. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.
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