Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) Antibody
169€ (20 µl)
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935106861
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name
Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320486
tested applications
ELISA, IHC
Description
TERF2IP Antibody is a Rabbit Polyclonal against TERF2IP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NYB0 |
| Gene ID | 54386 |
| OMIM | 605061 |
| Alias | RAP1,TERF2-interacting telomeric protein 1,TRF2-interacting telomeric protein 1,DRIP5 |
| Background | Antibody anti-TERF2IP |
| Status | RUO |
Descripción
TERF2IP, also known as RAP1, is a key component of the shelterin complex that interacts with TERF2 to regulate telomere protection and maintenance. While TERF2IP does not directly bind to telomeric DNA, it associates with TERF2 to stabilize telomeric t-loops, preventing chromosome end fusions and inappropriate activation of DNA damage signaling pathways. TERF2IP is also involved in non-telomeric functions, including transcriptional regulation, NF-κB signaling, and metabolic control, highlighting its broader cellular roles. It is widely expressed in proliferative tissues, where it maintains telomere length homeostasis and protects chromosome ends during replication. Dysregulation of TERF2IP has been linked to premature aging, genomic instability, and cancer, where altered shelterin function results in telomere dysfunction and increased susceptibility to DNA damage. Functional studies show that TERF2IP loss leads to telomere deprotection, chromosomal instability, and activation of p53-mediated cell cycle arrest, underscoring its essential role in telomere maintenance, genomic stability, and transcriptional regulation.
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