TERF2IP antibody
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935106861
info@markelab.com
name
TERF2IP antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08599
tested applications
ELISA, WB, IHC
Description
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | telomeric repeat binding factor 2, interacting protein (TERF2IP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NYB0 |
| Gene ID | 54386 |
| Alias | RAP1,TERF2-interacting telomeric protein 1,TRF2-interacting telomeric protein 1,DRIP5 |
| Background | Antibody anti-TERF2IP |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
TERF2IP, also known as RAP1, is a key component of the shelterin complex that interacts with TERF2 to regulate telomere protection and maintenance. While TERF2IP does not directly bind to telomeric DNA, it associates with TERF2 to stabilize telomeric t-loops, preventing chromosome end fusions and inappropriate activation of DNA damage signaling pathways. TERF2IP is also involved in non-telomeric functions, including transcriptional regulation, NF-κB signaling, and metabolic control, highlighting its broader cellular roles. It is widely expressed in proliferative tissues, where it maintains telomere length homeostasis and protects chromosome ends during replication. Dysregulation of TERF2IP has been linked to premature aging, genomic instability, and cancer, where altered shelterin function results in telomere dysfunction and increased susceptibility to DNA damage. Functional studies show that TERF2IP loss leads to telomere deprotection, chromosomal instability, and activation of p53-mediated cell cycle arrest, underscoring its essential role in telomere maintenance, genomic stability, and transcriptional regulation.
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