Tachykinin Receptor 1 (TACR1) Antibody
52€ (10 µg)
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935106861
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name
Tachykinin Receptor 1 (TACR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015349
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against Tachykinin Receptor 1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Tachykinin Receptor 1 (TACR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25103 |
| Alias | TACR1,SPR,Substance P receptor,NK1R,TAC1R,neurokinin receptor 1,NK1 receptor,NKIR |
| Background | Antibody anti-TACR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
TACR1 is a G protein-coupled receptor (GPCR) that is activated by neurokinin A (NKA) and substance P, which are neuropeptides from the tachykinin family. TACR1 primarily couples to Gq proteins, which activate phospholipase C (PLC), leading to the production of inositol triphosphate (IP3) and the release of intracellular calcium. This results in smooth muscle contraction, vasodilation, and increased cell signaling. TACR1 is expressed in various tissues, including the central nervous system (CNS), gastrointestinal tract, and vasculature. In the CNS, TACR1 regulates pain perception, mood, and anxiety, while in the gastrointestinal system, it is involved in regulating motility and inflammation. Dysregulation of TACR1 signaling has been implicated in pain disorders, such as chronic inflammatory pain, and conditions like asthma and irritable bowel syndrome (IBS). Targeting TACR1 with antagonists is being explored as a potential therapy for pain management and other inflammatory diseases.
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