T-Lymphocyte Activation Antigen CD86 / B7-2 (CD86) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-CD86
proveedor
Abbexareference
abx001112Tested Applications
ELISA, WB, IF/ICCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
CD86 Antibody is a Rabbit Polyclonal antibody against CD86. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
Background
CD86, also known as B7-2, is a transmembrane glycoprotein that plays a crucial role in the costimulatory signaling necessary for T-cell activation and immune response. It is a member of the immunoglobulin (Ig) superfamily and is encoded by the CD86 gene located on chromosome 3q21. CD86 is primarily expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The interaction of CD86 with its receptors, CD28 and CTLA-4 (CD152), on T cells is vital for regulating immune responses, influencing both the activation and inhibition of T cells.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
T-Lymphocyte Activation Antigen CD86 / B7-2 (CD86)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/1000 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CD86
dry ice
No
availability
Shipped within 5-10 working days.
alias
B70,B7-2,B7.2,LAB72,CD28LG2,Activation B7-2 antigen,BU63,CTLA-4 counter-receptor B7.2,FUN-1,T-lymphocyte activation antigen CD86
uniprot id
NCBI accession
NP_787058.4
note
Concentration: > 0.2 mg/ml -
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