T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Protein
234€ (5 µg)
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935106861
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name
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261254
tested applications
SDS-PAGE
Description
CD8B is a recombinant protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 80% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P10966 |
| Alias | LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain |
| Background | Protein CD8B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.
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