T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody
299€ (0.1 mg)
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Name
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140574
Tested Applications
IHC, FCM, IP
Description
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Antibody is a Rat Monoclonal against T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: T-Cell Surface Glycoprotein CD8 Beta Chain (CD8b) Immunogen: Mouse CD8b |
| Host | Rat |
| Reactivity | Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b Kappa |
| Clone ID | H971 |
| Purification | Purified by Protein G affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| Alias | LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain |
| Background | Antibody anti-CD8B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.
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