T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody
299€ (100 µl)
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935106861
info@markelab.com
name
T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx102990
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain |
| Background | Antibody anti-CD8B |
| Status | RUO |
Descripción
The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.
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