T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody

Name: T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Antibody
Brand: Abbexa
SKU: abx102989
Price: 299 EUR
Availability: OnlineOnly

Este producto es parte de CD8 subunit

Pida mas información

935106861

info@markelab.com

Precio

299€ (100 µl)

Antibody anti-CD8B

proveedor

Abbexa

reference

abx102989

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Polyclonal Antibody to Cluster Of Differentiation 8b (CD8b).

Background

The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

WB, IHC, IF/ICC

purification

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

recommended dilution

WB: 0.01-3 µg/ml, IHC: 5-30 µg/ml, IF/ICC: 5-30 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol.

size 1

100 µl

size 2

200 µl

size 3

1 ml

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

CD8B

dry ice

availability

Shipped within 5-7 working days.

alias

LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain

uniprot id

https://www.uniprot.org/uniprotkb/P10966

note

Concentration: 0.5 mg/ml -

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anti- CD8B antibody

proveedor

FineTest

reference

FNab01506

Tested Applications

ELISA, WB

reactivity

human

status

RUO

clonality

polyclonal

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in...

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