Human T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Protein
260€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065944
tested applications
WB, SDS-PAGE
Description
Recombinant Cluster Of Differentiation 8b (CD8b) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | T-Cell Surface Glycoprotein CD8 Beta Chain (CD8B) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 20.5 kDa Observed MW (SDS-PAGE): 21 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu22-Pro170 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10966 |
| Alias | LY3,P37,LEU2,LYT3,Ly-3,CD8B1,CD8beta,T-cell surface glycoprotein CD8 beta chain |
| Background | Protein CD8B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The CD8B gene encodes the beta subunit of the CD8 glycoprotein, which typically pairs with CD8A to form the CD8αβ heterodimer. This structure is primarily expressed on cytotoxic T lymphocytes (CTLs), enabling T-cell recognition of MHC class I-peptide complexes. CD8B plays a key role in enhancing TCR signaling and antigen-specific responses by associating with the intracellular signaling protein Lck (lymphocyte-specific protein tyrosine kinase). Unlike CD8A, CD8B is required for high-affinity TCR interactions, making it critical for T-cell activation and target cell lysis. CD8B expression is tightly regulated during T-cell development in the thymus. Dysregulation of CD8B may lead to impaired immune responses, contributing to susceptibility to infections and autoimmune disorders.
Related Products
CD8B antibody
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Ver Producto
Recombinant Human CD8B
Ver Producto