T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody
292.5€ (80 µl)
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935106861
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name
T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028446
tested applications
ELISA, WB, IHC, FCM
Description
CD3G is the CD3-gamma polypeptide, which together with CD3-epsilon, delta and zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in the CD3G gene are associated with T cell immunodeficiency.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Surface Glycoprotein CD3 Gamma Chain (CD3G) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS, then purified by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09693 |
| NCBI Accession | NP_000064.1 |
| Alias | T3G,IMD17,CD3GAMMA,CD3-GAMMA,T-cell surface glycoprotein CD3 gamma chain,T-cell receptor T3 gamma chain |
| Background | Antibody anti-CD3G |
| Status | RUO |
Descripción
CD3G, the gamma subunit of the T-cell receptor (TCR) complex, is a crucial component of the TCR-CD3 complex, which plays an essential role in T-cell activation, signal transduction, and immune responses. The TCR-CD3 complex is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This recognition initiates signaling cascades that activate T cells, leading to immune responses such as T-cell proliferation, cytokine production, and differentiation into effector cells. The CD3 complex consists of multiple subunits, including CD3G (gamma), CD3E (epsilon), CD3D (delta), and CD3Z (zeta), which associate with the TCR α/β or γ/δ heterodimers to form the full TCR-CD3 complex. The CD3G gene is located on chromosome 11q23, adjacent to the CD3D gene. It encodes the CD3γ chain, a transmembrane protein that is integral to the structural stability and function of the TCR-CD3 complex. CD3G is expressed on the surface of all mature T lymphocytes and certain natural killer (NK) cells, where it contributes to immune surveillance, host defense against infections, and recognition of transformed cells (e.g., tumor cells).
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CD3G is the CD3-gamma polypeptide, which together with CD3-epsilon, delta and zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in the CD3G gene are associated with T cell immunodeficiency.
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