T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody (Biotin)

Este producto es parte de CD3E - CD3 epsilon subunit of T-cell receptor complex
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338€ (100 µl)

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935106861
info@markelab.com
name
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx159387
tested applications
ELISA, IF/ICC, FCM

Description

CD3E Antibody (Biotin) is a Mouse Monoclonal against CD3E.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E)
Host
Mouse
Reactivity
Human
Recommended Dilution
IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Biotin
Isotype
IgG2a
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, IF/ICC, FCM
Buffer
PBS, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07766
Gene ID
916
OMIM
186830
Alias
T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain
Background
Antibody anti-CD3E
Status
RUO

Descripción

CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.

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