T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody

Este producto es parte de CD3E - CD3 epsilon subunit of T-cell receptor complex
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383.5€ (100 µl)

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935106861
info@markelab.com
name
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010520
tested applications
ELISA, FCM

Description

CD3 is a component of T cell surface receptor (TCR), it cantains 5 invariable chains: gamma, delta, epsilon-, and zeta/eta. Clevers et al. (1988) showed the TCR/CD3 complex consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits, CD3 is responsible for the signal transduction of the TCR.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E)
Host
Mouse
Reactivity
Human
Recommended Dilution
ELISA: 1/10000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2a
Purification
Unpurified ascites.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, FCM
Buffer
Ascitic fluid containing 0.03% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07766
Gene ID
919
OMIM
186830
Alias
T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain
Background
Antibody anti-CD3E
Status
RUO
Note
Concentration: Not determined. -

Descripción

CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.

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