T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody (APC)

689€ (100 tests)
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935106861
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name
T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx270544
tested applications
FCM
Description
T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) Antibody (APC) is a Rabbit Polyclonal Antibody conjugated to APC against T-Cell Surface Glycoprotein CD3 Epsilon (CD3e) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) |
Host | Rabbit |
Reactivity | Mouse |
Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | APC |
Isotype | IgG |
Purification | Purified by antigen-specific affinity chromatography. |
Size 1 | 100 tests |
Size 2 | 200 tests |
Size 3 | 500 tests |
Form | Liquid |
Tested Applications | FCM |
Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
Availability | Shipped within 5-15 working days. |
Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
Dry Ice | No |
Alias | T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain |
Background | Antibody anti-CD3E |
Status | RUO |
Descripción
CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.
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