T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody

299€ (50 µl)
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935106861
info@markelab.com
name
T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx349870
tested applications
ELISA, FCM
Description
T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human CD3E.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | T-cell surface glycoprotein CD3 epsilon chain (CD3E) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | FCM: 1/20 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Expression | Recombinant |
Purification | Purified by affinity chromatography. |
Size 1 | 50 µl |
Size 2 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, FCM |
Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P07766 |
Gene ID | 916 |
Alias | T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain |
Background | Antibody anti-CD3E |
Status | RUO |
Descripción
CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.
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