T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody

Este producto es parte de CD3E - CD3 epsilon subunit of T-cell receptor complex
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299€ (50 µl)

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935106861
info@markelab.com
name
T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx349870
tested applications
ELISA, FCM

Description

T-cell surface glycoprotein CD3 epsilon chain (CD3E) Antibody is a Recombinant Mouse Monoclonal antibody for the detection of Human CD3E.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
T-cell surface glycoprotein CD3 epsilon chain (CD3E)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 1/20 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG
Expression
Recombinant
Purification
Purified by affinity chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, FCM
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07766
Gene ID
916
Alias
T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain
Background
Antibody anti-CD3E
Status
RUO

Descripción

CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.

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