T-Cell Surface Glycoprotein Cd1E, Membrane-Associated (CD1E) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
CD1E encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-Cell Surface Glycoprotein Cd1E, Membrane-Associated (CD1E) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15812 |
| Alias | R2,CD1A,T-cell surface glycoprotein CD1e membrane-associated,hCD1e,R2G1 |
| Background | Antibody anti-CD1E |
| Status | RUO |
Descripción
CD1E molecule is a member of the CD1 family of glycoproteins, which are antigen-presenting molecules structurally related to the major histocompatibility complex (MHC) class I proteins. CD1 proteins are unique in their ability to present lipid and glycolipid antigens rather than peptide antigens, which are typically presented by MHC molecules. CD1E plays a specialized role within the CD1 family, particularly in the intracellular processing and presentation of lipid antigens, distinguishing it from other CD1 molecules that are predominantly involved in antigen presentation at the cell surface. CD1E is critical for the proper functioning of lipid antigen presentation, especially in professional antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. While other CD1 family members (e.g., CD1A, CD1B, CD1C, and CD1D) directly present lipid antigens to T cells, CD1E’s primary function is to facilitate the processing of complex lipids into smaller components that can be presented by other CD1 molecules. This intracellular processing is essential for generating the lipid antigens that eventually engage T cells, such as natural killer T (NKT) cells or conventional T cells, in the immune response to pathogens like mycobacteria, fungi, and certain viruses.
Related Products
T-Cell Surface Glycoprotein Cd1E, Membrane-Associated (CD1E) Antibody
Rabbit polyclonal antibody against CD1E protein. Immunogen region is Internal.
Ver Producto
T-Cell Surface Glycoprotein Cd1E, Membrane-Associated (CD1E) Antibody
CD1E encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.
Ver Producto
T-Cell Surface Glycoprotein Cd1E, Membrane-Associated (CD1E) Antibody
Cluster Of Differentiation 1e Antibody is a Rabbit Polyclonal against Cluster Of Differentiation 1e.
Ver Producto