T-cell Surface Glycoprotein CD1c (CD1C) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
T-cell Surface Glycoprotein CD1c (CD1C) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139086
tested applications
IHC, FCM, IP
Description
CD1c Antibody is a Mouse Monoclonal against CD1c.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-cell Surface Glycoprotein CD1c (CD1C) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | I754 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P29017 |
| Gene ID | 911 |
| Alias | R7,CD1,CD1A,BDCA1,T-cell surface glycoprotein CD1c |
| Background | Antibody anti-CD1C |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The CD1C molecule is a member of the CD1 family of glycoproteins, which play a critical role in the immune system by presenting lipid and glycolipid antigens to T cells. Unlike major histocompatibility complex (MHC) class I and II molecules, which primarily present peptide antigens, CD1 molecules specialize in the presentation of lipids, making them essential players in immune responses against lipid-containing pathogens like mycobacteria. CD1C, in particular, is one of the most studied isoforms in the CD1 family due to its role in presenting antigens to T cells, especially CD1c-restricted T cells, which are important in the defense against bacterial infections, especially those involving mycobacteria. CD1C is expressed predominantly on antigen-presenting cells (APCs), such as dendritic cells, B cells, and macrophages, which are crucial for initiating adaptive immune responses. The molecule plays a significant role in shaping the immune response to lipid antigens, facilitating the recognition and elimination of microbial invaders, especially those with complex lipid envelopes, such as Mycobacterium tuberculosis
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