T-cell Surface Glycoprotein CD1b (CD1B) Antibody
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Description
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq].
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | T-cell Surface Glycoprotein CD1b (CD1B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29016 |
| Alias | R1,CD1,CD1A,T-cell surface glycoprotein CD1b |
| Background | Antibody anti-CD1B |
| Status | RUO |
Descripción
CD1B is a transmembrane glycoprotein that belongs to the CD1 family, which is structurally related to major histocompatibility complex (MHC) class I molecules. Encoded by the CD1B gene, it is primarily involved in the presentation of lipid and glycolipid antigens to T-cells, particularly a subset of T-cells known as invariant natural killer T-cells (iNKT). CD1B molecules are critical for immune responses to mycobacterial and other pathogen-derived lipids. Unlike MHC molecules, CD1B specializes in presenting lipid-based antigens rather than peptide antigens. It is expressed on antigen-presenting cells (APCs) such as dendritic cells, monocytes, and certain thymocytes.
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