Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody (HRP)

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169€ (20 µg)

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935106861
info@markelab.com
name
Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx305371
tested applications
ELISA

Description

SMNDC1 Antibody (HRP) is a Rabbit Polyclonal against SMNDC1 conjugated to HRP.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O75940
Gene ID
10285
OMIM
603519
Background
Antibody anti-SMNDC1
Status
RUO

Descripción

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Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody

SMNDC1 Antibody is a Rabbit Polyclonal antibody against SMNDC1. SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

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