SMNDC1 antibody
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Description
Necessary for spliceosome assembly. Overexpression causes apoptosis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | survival motor neuron domain containing 1 (SMNDC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O75940 |
| Gene ID | 10285 |
| Alias | Survival of motor neuron-related-splicing factor 30,30 kDa splicing factor SMNrp,SMN-related protein,Survival motor neuron domain-containing protein 1,SMNDC1,SMNR,SPF30 |
| Background | Antibody anti-SMNDC1 |
| Status | RUO |
| Note | Mol. Weight 32 kDa |
Descripción
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Recombinant Human SMNDC1
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Survival of Motor Neuron-Related-Splicing Factor 30 (SMNDC1) Antibody
SMNDC1 Antibody is a Rabbit Polyclonal antibody against SMNDC1. SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
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