Suppressors Of Cytokine Signaling 1 (SOCS1) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Suppressors Of Cytokine Signaling 1 (SOCS1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241107
Tested Applications
ELISA, WB, IHC
Description
SOCS1 Antibody is a Rabbit Polyclonal against SOCS1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressors Of Cytokine Signaling 1 (SOCS1) Immunogen: Synthetic peptide of human SOCS1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15524 |
| Gene ID | 8651 |
| Alias | AISIMD,CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP-3,TIP3 |
| Background | Antibody anti-SOCS1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SOCS1 is a critical negative regulator of cytokine signaling pathways, particularly those mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) system. It functions by directly binding to JAKs through its SH2 domain and targeting them for proteasomal degradation via its SOCS box, which recruits components of the ubiquitin-proteasome machinery. SOCS1 regulates immune responses by preventing excessive cytokine signaling, particularly in interferon-γ, IL-6, and IL-4 pathways, ensuring proper immune homeostasis and inflammation control. It is highly expressed in immune cells, including T cells, macrophages, and dendritic cells, where it regulates processes like cytokine sensitivity, inflammation, and T-cell activation. Dysregulation of SOCS1 contributes to autoimmune diseases, chronic inflammation, and cancer due to hyperactivation of cytokine signaling. Knockout studies reveal severe inflammatory responses, lymphocyte activation, and neonatal lethality, underscoring its essential role in immune regulation and cytokine signaling balance.
Productos relacionados
Suppressor of Cytokine Signaling 1 (SOCS1) Antibody
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), famil…
Ver producto Suppressor of Cytokine Signaling 1 (SOCS-1) Antibody
Suppressor of cytokine signaling 1 Antibody is a Rabbit Polyclonal antibody against Suppressor of cytokine signaling 1.…
Ver producto
Suppressor of Cytokine Signaling 1 (SOCS1) Antibody
SOCS1 Antibody is a Rabbit Polyclonal Antibody against SOCS1.…
Ver producto