Suppressor of Cytokine Signaling 1 (SOCS1) Antibody
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Description
SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Suppressor of Cytokine Signaling 1 (SOCS1) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15524 |
| NCBI Accession | NP_003736.1 |
| Alias | AISIMD,CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP-3,TIP3 |
| Background | Antibody anti-SOCS1 |
| Status | RUO |
Descripción
SOCS1 is a critical negative regulator of cytokine signaling pathways, particularly those mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) system. It functions by directly binding to JAKs through its SH2 domain and targeting them for proteasomal degradation via its SOCS box, which recruits components of the ubiquitin-proteasome machinery. SOCS1 regulates immune responses by preventing excessive cytokine signaling, particularly in interferon-γ, IL-6, and IL-4 pathways, ensuring proper immune homeostasis and inflammation control. It is highly expressed in immune cells, including T cells, macrophages, and dendritic cells, where it regulates processes like cytokine sensitivity, inflammation, and T-cell activation. Dysregulation of SOCS1 contributes to autoimmune diseases, chronic inflammation, and cancer due to hyperactivation of cytokine signaling. Knockout studies reveal severe inflammatory responses, lymphocyte activation, and neonatal lethality, underscoring its essential role in immune regulation and cytokine signaling balance.
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This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
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