Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) Antibody
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Description
SUV39H2 Antibody is a Rabbit Polyclonal antibody against SUV39H2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Suppressor of Variegation 3-9 Homolog 2 (SUV39H2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, ChIP: 5 µg antibody per 10 µg - 15 µg of Chromatin. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, ChIP |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H5I1 |
| Gene ID | 79723 |
| NCBI Accession | NP_001180354.1 |
| Background | Antibody anti-SUV39H2 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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SUV39H2 antibody
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1(CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.
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SUV39H2 Antibody is a Rabbit Polyclonal antibody against SUV39H2.
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