Suppressor Of Cytokine Signaling 6 (SOCS6) Antibody
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Description
SOCS6 Antibody is a Rabbit Polyclonal against SOCS6.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Suppressor Of Cytokine Signaling 6 (SOCS6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14544 |
| Gene ID | 9306 |
| Alias | SOSC6,CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4 |
| Background | Antibody anti-SOCS6 |
| Status | RUO |
Descripción
SOCS6 is a member of the SOCS protein family that regulates cytokine and growth factor signaling pathways, particularly those mediated by insulin and receptor tyrosine kinases (RTKs). It inhibits signaling by targeting receptor complexes and signaling intermediates for ubiquitin-mediated degradation via its SOCS box domain, thus fine-tuning pathways such as the PI3K/Akt and MAPK cascades. SOCS6 is broadly expressed in tissues like the liver, pancreas, and skeletal muscle, where it regulates processes like cell growth, glucose metabolism, and insulin sensitivity. It has a role in tumor suppression by inhibiting growth factor signaling and promoting apoptosis in cancer cells. Dysregulation of SOCS6 is linked to metabolic disorders, including insulin resistance and diabetes, as well as cancer progression due to impaired signaling control. Knockdown studies reveal enhanced RTK activity, increased cellular proliferation, and reduced apoptosis, highlighting its role as a regulator of metabolic signaling, growth, and tumor suppression.
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