Suppressor of Cytokine Signaling 5 (SOCS5) Antibody
637€ (100 µl)
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935106861
info@markelab.com
name
Suppressor of Cytokine Signaling 5 (SOCS5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx115908
tested applications
ELISA, WB
Description
Suppressor Of Cytokine Signaling 5 Antibody is a Rabbit Polyclonal antibody against Suppressor Of Cytokine Signaling 5.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Suppressor of Cytokine Signaling 5 (SOCS5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75159 |
| Gene ID | 9655 |
| OMIM | 607094 |
| Alias | SOCS5,CIS6, CISH6, Cish5, SOCS-5,Cytokine-inducible SH2 protein 6,CIS-6,Cytokine-inducible SH2-containing protein 5,Cytokine-inducible SH2-containing protein 5 |
| Background | Antibody anti-SOCS5 |
| Status | RUO |
Descripción
SOCS5 acts as a negative regulator of cytokine signaling by inhibiting JAK/STAT pathways and targeting signaling components for proteasomal degradation through its SOCS box domain. It interacts with cytokine receptors like IL-4Rα to regulate T-helper cell differentiation, particularly inhibiting Th2 responses and promoting immune balance. SOCS5 is expressed in lymphoid tissues, epithelial cells, and adipose tissues, where it modulates immune regulation, cytokine sensitivity, and energy homeostasis. It is particularly important for regulating allergic inflammation and T-cell polarization during immune responses. Dysregulation of SOCS5 is associated with allergic diseases, asthma, and autoimmune disorders due to imbalanced cytokine signaling. Functional studies reveal its role in controlling IL-4-driven responses, preventing excessive Th2-mediated inflammation. Knockout models demonstrate enhanced Th2 differentiation, increased allergic inflammation, and disrupted immune balance, emphasizing its role in maintaining cytokine homeostasis and adaptive immunity.
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