Suppressor of Cytokine Signaling 4 (SOCS4) Antibody
351€ (100 µg)
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Name
Suppressor of Cytokine Signaling 4 (SOCS4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx375761
Tested Applications
ELISA, WB
Description
Suppressor of Cytokine Signaling 4 (SOCS4) Antibody is a Rabbit Polyclonal antibody against Suppressor of Cytokine Signaling 4 (SOCS4).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Suppressor of Cytokine Signaling 4 (SOCS4) Immunogen: Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WXH5 |
| Gene ID | 122809 |
| Alias | SOCS-4,Suppressor of cytokine signaling 7,SOCS-7 |
| Background | Antibody anti-SOCS4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SOCS4 is a member of the SOCS protein family that regulates cytokine signaling by inhibiting the Janus kinase (JAK)/STAT pathway and promoting the proteasomal degradation of signaling intermediates via its SOCS box domain. It interacts with phosphorylated cytokine receptors and downstream proteins to suppress excessive cytokine responses, particularly in pathways related to epidermal growth factor receptor (EGFR) and interleukin-4 (IL-4). SOCS4 is broadly expressed in tissues such as the liver, immune cells, and epithelial tissues, where it regulates processes like cell proliferation, differentiation, and immune homeostasis. It has been implicated in regulating inflammation and epithelial repair during infections. Dysregulation of SOCS4 is linked to chronic inflammation, impaired wound healing, and cancer progression, where excessive EGFR signaling promotes uncontrolled cell proliferation. Knockdown studies reveal hyperactivated cytokine signaling, increased inflammatory responses, and abnormal cellular growth, highlighting its critical role in balancing cytokine-mediated signaling pathways.
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