Structural Maintenance of Chromosomes 5 (SMC5) Peptide
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Description
Structural Maintenance of Chromosomes 5 (SMC5) Peptide is a synthetic peptide.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Structural Maintenance of Chromosomes 5 (SMC5) |
| Host | Synthetic |
| Recommended Dilution | BL (predicted): 0.5 mg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: Internal region: C-TSKHLEHKDNELRQ |
| Size 1 | 100 µg |
| Form | Lyophilized Reconstitute in deionized water. |
| Tested Applications | P-ELISA |
| Buffer | Prior to lyophilization: Deionized water. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 23137, 226026, 293967 |
| NCBI Accession | NP_055925.2 |
| Background | Protein SMC5 |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
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