SMC5 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | structural maintenance of chromosomes 5 (SMC5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120-130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8IY18 |
| Gene ID | 23137 |
| Alias | Structural maintenance of chromosomes protein 5 (SMC protein 5, SMC-5, hSMC5),SMC5,KIAA0594,SMC5L1 |
| Background | Antibody anti-SMC5 |
| Status | RUO |
| Note | Mol. Weight 120-130 kDa |
Descripción
Related Products
SMC5 antibody
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
Ver Producto
Structural Maintenance of Chromosomes 5 (SMC5) Antibody
SMC5 Antibody is a Rabbit Polyclonal antibody against SMC5.
Ver Producto
Structural Maintenance of Chromosomes 5 (SMC5) Antibody
Structural Maintenance Of Chromosomes 5 Antibody is a Rabbit Polyclonal antibody against Structural Maintenance Of Chromosomes 5.
Ver Producto