Structural Maintenance Of Chromosomes 5 (SMC5) Antibody (Biotin)
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Description
SMC5 Antibody (Biotin) is a Rabbit Polyclonal against SMC5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Structural Maintenance Of Chromosomes 5 (SMC5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IY18 |
| Gene ID | 23137 |
| Background | Antibody anti-SMC5 |
| Status | RUO |
Descripción
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SMC5 antibody
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
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Structural Maintenance of Chromosomes 5 (SMC5) Antibody
SMC5 Antibody is a Rabbit Polyclonal antibody against SMC5.
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Structural Maintenance of Chromosomes 5 (SMC5) Antibody
Structural Maintenance Of Chromosomes 5 Antibody is a Rabbit Polyclonal antibody against Structural Maintenance Of Chromosomes 5.
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