Stromal Interaction Molecule 1 (STIM1) Antibody (HRP)
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Description
STIM1 Antibody (HRP) is a Rabbit Polyclonal against STIM1 conjugated to HRP.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Stromal Interaction Molecule 1 (STIM1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13586 |
| Gene ID | 6786 |
| NCBI Accession | NP_001264891.1, NM_001277962.1, NP_003147.2, NM_003156.3 |
| OMIM | 160565 |
| Background | Antibody anti-STIM1 |
| Status | RUO |
Descripción
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STIM1 antibody
STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.
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Plays a role in mediating store-operated Ca(2+) entry(SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores(By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+)(CRAC) channel subunit ORAI1(PubMed:16208375). Involved in enamel formation(By similarity). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch(By similarity).
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