STIP1 Homology And U-Box Containing Protein 1 (STUB1) Antibody

Descripción

STUB1 Antibody is a Rabbit Polyclonal antibody against STUB1. The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome systemCytoplasmic CHIP protein contains three 34-amino acid TPR (tetRatricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domainCHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domainThe binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substRatesCHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and α-synuclein.