Sphingosine 1-Phosphate Receptor 2 (S1PR2) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Sphingosine 1-Phosphate Receptor 2 (S1PR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx237569
tested applications
ELISA, WB
Description
S1PR2 Antibody is a Rabbit Polyclonal against S1PR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Sphingosine 1-Phosphate Receptor 2 (S1PR2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95136 |
| Gene ID | 9294 |
| Alias | S1PR2,AGR16,DFNB68,EDG-5,EDG5,Gpcr13,H218,LPB2,S1P2,endothelial differentiation G protein-coupled receptor 5,G protein-coupled receptor 13,GPCR18 ,S1P receptor 2 |
| Background | Antibody anti-S1PR2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
S1PR2 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), a bioactive lipid that regulates cell migration, proliferation, and vascular integrity. S1PR2 is expressed in endothelial cells, smooth muscle cells, and immune cells, where it couples primarily to G12/13 and Gq proteins. Its activation triggers downstream pathways, including Rho/ROCK and phospholipase C (PLC), leading to actin cytoskeletal reorganization and calcium signaling. S1PR2 plays critical roles in maintaining vascular tone, regulating endothelial barrier integrity, and inhibiting cell migration. It also contributes to immune cell retention in tissues, modulating inflammation and immune responses. Dysregulation of S1PR2 has been linked to inflammatory diseases, cardiovascular dysfunction, and neurodegeneration. In cancer, S1PR2 can act as a tumor suppressor by inhibiting migration and metastasis; however, in some contexts, it promotes inflammation and tumor progression. Targeting S1PR2 is under investigation for therapeutic applications in inflammation, vascular diseases, and cancer.
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