Somatostatin Receptor Type 2 (SSTR2) Antibody

Este producto es parte de SSTR - Somatostatin Receptor
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169€ (20 µg)

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935106861
info@markelab.com
name
Somatostatin Receptor Type 2 (SSTR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx317864
tested applications
ELISA, WB, IHC, IF/ICC

Description

SSTR2 Antibody is a Rabbit Polyclonal against SSTR2.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Somatostatin Receptor Type 2 (SSTR2)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P30874
Gene ID
6752
NCBI Accession
NP_001041.1
OMIM
182452
Alias
SSTR2,somatotropin release-inhibiting factor receptor,SRIF-1,SST2
Background
Antibody anti-SSTR2
Status
RUO
Note
Concentration: 4 mg/ml -

Descripción

SSTR2 is another member of the somatostatin receptor family, primarily activated by somatostatin. Like SSTR1, SSTR2 also couples to Gi proteins to inhibit adenylate cyclase and reduce cAMP levels. It is expressed in a variety of tissues, including the pituitary gland, pancreas, and gastrointestinal tract, and plays a crucial role in regulating the secretion of growth hormone, insulin, and other hormones. SSTR2 is particularly important in inhibiting the release of growth hormone from the pituitary and in controlling insulin release from pancreatic β-cells. It is also implicated in regulating gastrointestinal motility and digestive enzyme secretion. Dysregulation of SSTR2 signaling is often found in tumors, particularly neuroendocrine tumors, where increased hormone secretion occurs. SSTR2 agonists, like somatostatin analogs, are used in the clinical management of conditions such as acromegaly, carcinoid syndrome, and other endocrine-related disorders, where they help control hormone levels and reduce tumor growth.

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Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

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