SSTR2 antibody

Este producto es parte de SSTR - Somatostatin Receptor
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
SSTR2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08253
tested applications
ELISA, IHC, WB

Description

Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Documents del producto

Instrucciones
Descargar
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
somatostatin receptor 2 (SSTR2)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:1000; IHC: 1:50-1:100
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
41 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, WB
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P30874
Gene ID
6752
Alias
SSTR2,somatotropin release-inhibiting factor receptor,SRIF-1,SST2
Background
Antibody anti-SSTR2
Status
RUO
Note
Mol. Weight 41 kDa

Descripción

SSTR2 is another member of the somatostatin receptor family, primarily activated by somatostatin. Like SSTR1, SSTR2 also couples to Gi proteins to inhibit adenylate cyclase and reduce cAMP levels. It is expressed in a variety of tissues, including the pituitary gland, pancreas, and gastrointestinal tract, and plays a crucial role in regulating the secretion of growth hormone, insulin, and other hormones. SSTR2 is particularly important in inhibiting the release of growth hormone from the pituitary and in controlling insulin release from pancreatic β-cells. It is also implicated in regulating gastrointestinal motility and digestive enzyme secretion. Dysregulation of SSTR2 signaling is often found in tumors, particularly neuroendocrine tumors, where increased hormone secretion occurs. SSTR2 agonists, like somatostatin analogs, are used in the clinical management of conditions such as acromegaly, carcinoid syndrome, and other endocrine-related disorders, where they help control hormone levels and reduce tumor growth.

Related Products

EH2204

Human SSTR2 (Somatostatin receptor type 2) ELISA Kit

Ver Producto
ER1935

Rat SSTR2 (Somatostatin receptor type 2) ELISA Kit

Ver Producto
FNab08253

SSTR2 antibody

Receptor for somatostatin-14 and-28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha-and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Ver Producto