Somatostatin Receptor 4 (SSTR4) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Somatostatin Receptor 4 (SSTR4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015478
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against SSTR4 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Somatostatin Receptor 4 (SSTR4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31391 |
| Alias | SSTR4,SRIF2B,SS-4-R,SS4-R, SS4R,SST4 |
| Background | Antibody anti-SSTR4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
SSTR4 is a G protein-coupled receptor that binds somatostatin, a peptide hormone involved in inhibiting the release of other hormones such as growth hormone, insulin, and glucagon. It primarily couples to Gi proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which results in the suppression of hormone secretion and modulation of cellular responses. SSTR4 is expressed in a variety of tissues, including the brain, pancreas, and gastrointestinal tract. In the brain, it plays a role in regulating neurotransmitter release and synaptic transmission. In the pancreas, it helps to control insulin and glucagon secretion, contributing to glucose homeostasis. Dysregulation of SSTR4 has been implicated in disorders such as acromegaly and diabetes. Somatostatin analogs that target SSTR4 are used therapeutically to control excessive hormone secretion, particularly in endocrine tumors and hormone-related disorders.
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