Somatostatin Receptor 1 (SSTR1) Antibody
52€ (10 µg)
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Name
Somatostatin Receptor 1 (SSTR1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015477
Tested Applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against SSTR1 protein. Immunogen region is N-terminal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Somatostatin Receptor 1 (SSTR1) Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human SSTR1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30872 |
| Alias | SSTR1,SRIF-2,SS1R,SRIF-2,SS-1-R,SS1-R,SST1 |
| Background | Antibody anti-SSTR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SSTR1 is a G protein-coupled receptor (GPCR) that binds somatostatin, a peptide hormone that inhibits the release of various other hormones, including growth hormone, insulin, and glucagon. SSTR1 is predominantly expressed in the brain, pancreas, and gastrointestinal tract. It primarily couples to Gi proteins, inhibiting adenylate cyclase activity and reducing cAMP levels, which leads to the suppression of hormone secretion and modulation of neurotransmitter release. In the central nervous system, SSTR1 regulates neurotransmission and has a role in inhibiting secretion of growth hormone from the pituitary. Dysregulation of SSTR1 signaling is implicated in disorders like acromegaly, diabetes, and certain neuroendocrine tumors, where excessive hormone secretion or abnormal growth occurs. SSTR1 agonists, such as octreotide, are used therapeutically to treat conditions such as acromegaly and neuroendocrine tumors by inhibiting growth hormone and other secretions.
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