SIRT2 Antibody is a Rabbit Polyclonal antibody against SIRT2. Sirtuins are members of the NAD-dependent histone deacetylase family of proteins that participate in a variety of cellular functions, including histone deacetylation, gene silencing, chromosomal stability, and agingSIRT2, a human homolog of the yeast SIR2 (silent information regulator-2), functions as transcriptional silencing mediator at mating-type loci, telomeres and ribosomal gene clustersSIRT2 expression increases dramatically during mitosis and is multiply phosphorylated at the G(2)/M transition of the cell cycleSIRT2 is part of a phosphorylation cascade where it is phosphorylated late in G(2), during M, and into the period of cytokinesisInhibition of SIRT2 is reported to rescue alpha-synuclein toxicity and modify inclusion morphology in a cellular model of Parkinsons disease.
Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT2 participates in regulating microtubule acetylation, controlling myelination in the central and peripheral nervous systems, and influencing gluconeogenesis.
Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT2 participa en la regulación de la acetilación de los microtúbulos, controla la mielinización en los sistemas nerviosos central y periférico e influye en la gluconeogénesis.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Sirtuin 2 (SIRT2)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SIRT2
No
Shipped within 5-10 working days.
SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2
This product is for research use only.
Sirtuin 2 Antibody is a Rabbit Polyclonal antibody against Sirtuin 2.
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