Sirtuin 2 (SIRT2) Antibody

Este producto es parte de SIRT2 - Sirtuin 2
Product Graph
273€ (100 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Sirtuin 2 (SIRT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx100644
tested applications
WB, IHC, IF/ICC

Description

Polyclonal Antibody to Sirtuin 2 (SIRT2).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Sirtuin 2 (SIRT2)
Host
Rabbit
Reactivity
Rat
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q5RJQ4
Alias
SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2
Background
Antibody anti-SIRT2
Status
RUO

Descripción

SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration

Related Products

abx214319

Sirtuin 2 (SIRT2) Antibody

SIRT2 Antibody is a Rabbit Polyclonal against SIRT2.

Ver Producto
abx263271

Sirtuin-2 Protein

SIRT2 is a recombinant protein.

Ver Producto
abx383209

Human Sirtuin 2 (SIRT2) ELISA Kit

Human Sirtuin 2 (SIRT2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sirtuin 2 concentrations in tissue homogenates, cell lysates and other biological fluids.

Ver Producto