Sirtuin 2 (SIRT2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

43.75€ (10 µg)

proveedor

Abbexa

reference

abx015144

Tested Applications

ELISA, WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

Rabbit polyclonal antibody against SIRT2 protein. Immunogen region is C-terminal.

Background

Sirtuins are a family of signaling proteins that play a crucial role in metabolic regulation. They are classified into two main types based on their enzymatic activities: mono-ADP-ribosyltransferases or deacylases. Sirtuins are involved in influencing a wide range of cellular processes, including aging, transcription, apoptosis, inflammation, and stress resistance. In humans, there are seven types of sirtuins known as SIRT1 through SIRT7. The first Sirtuin, Sir2, was initially discovered in yeast. SIRT2 participates in regulating microtubule acetylation, controlling myelination in the central and peripheral nervous systems, and influencing gluconeogenesis.

Background

Las sirtuinas son una familia de proteínas de señalización que desempeñan un papel crucial en la regulación metabólica. Se clasifican en dos tipos principales según su actividad enzimática: mono-ADP-ribosiltransferasas o desacilasas. Las sirtuinas influyen en una amplia gama de procesos celulares, incluidos el envejecimiento, la transcripción, la apoptosis, la inflamación y la resistencia al estrés. En los seres humanos, existen siete tipos de sirtuinas conocidas como SIRT1 a SIRT7. La primera Sirtuin, Sir2, se descubrió inicialmente en levaduras. SIRT2 participa en la regulación de la acetilación de los microtúbulos, controla la mielinización en los sistemas nerviosos central y periférico e influye en la gluconeogénesis.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat

immunogen target

Sirtuin 2 (SIRT2)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.

buffer

PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.

size 1

10 µg

size 2

100 µg

size 3

200 µg

size 4

300 µg

size 5

1 mg

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SIRT2

dry ice

availability

Shipped within 5-10 working days.

alias

SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2

uniprot id

https://www.uniprot.org/uniprotkb/Q8IXJ6

note

This product is for research use only.

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